Hemostasis is the state of balance in the blood's coagulation system. There are 13 blood coagulation factors and other proteins found in human blood. In a normal, healthy individual, factors interact with one another, performing a series of complex reactions that eventually cause a clot to form, which stops bleeding.
An individual with a coagulation disorder is missing or deficient in one of these factors, and normal blood coagulation cannot occur. Such an individual also might lack the protective mechanism that stops or inactivates these coagulation factors; this can cause their blood to clot abnormally.
Derived from human plasma, the liquid part of blood, or through the use of recombinant technology, hemostasis products help individuals who have hemophilia or antithrombin III deficiency.
Koate®-DVI, Antihemophilic Factor (Human) is a plasma derived product for the treatment of classic hemophilia (hemophilia A) in which there is a demonstrated deficiency of activity of the plasma clotting factor, factor VIII.
Antithrombin III (AT III) is a blood protein that inhibits or stops the clotting factors in blood. Approximately 75 percent of the body’s plasma coagulation inhibitory activity is derived from AT III.
AT III deficiency is a rare inherited or spontaneously occurring condition that affects one in every 2,000 to 5,000 males and females worldwide. Individuals with the condition lack the AT III protein and spontaneous clotting can occur in the legs, arms, intestines, brain, kidney, eye, or other organs such as the heart and lungs as a result of normal, daily activity. In individuals with AT III deficiency, these clots can damage vital organs.
Thrombate® III, Antithrombin III (Human), is a sterile, nonpyrogenic, stable, lyophilized preparation of purified human antithrombin III (AT III).
Please refer to the WARNINGS section of the Koate-DVI package insert by clicking here or the WARNINGS section of the Thrombate III package insert by clicking here.
Remember, your doctor or healthcare provider is the single best source of information regarding you and your health. Please consult your doctor if you have any questions about your health, your symptoms, or your therapy.
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